women taking menopause pills
PCOS and Menopause: What You Should Know This PCOS Awareness Month

Polycystic Ovary Syndrome (PCOS) is often thought of as a condition that primarily affects younger women, but its impact doesn’t end there. As more people with PCOS enter perimenopause and menopause, research is shedding light on how symptoms and risks change, and what steps you can take to protect your health during this important stage of life.

What Is PCOS?

PCOS is a hormonal disorder that affects how the ovaries work. It often leads to irregular or missed periods, higher levels of male-type hormones (androgens), and insulin resistance. Many women experience symptoms such as acne, increased facial or body hair, fertility challenges, and weight gain. Importantly, PCOS is a lifelong condition—it does not simply go away with age or once menstruation stops.

What Happens During Perimenopause and Menopause

Perimenopause is the transitional period before menopause when estrogen and progesterone levels begin to fluctuate. This stage can last for several years and is often marked by irregular cycles, hot flashes, and mood changes. Menopause, on the other hand, is defined as 12 consecutive months without a menstrual period and signals the end of natural ovarian hormone production.

Research shows that women with PCOS often reach menopause a little later than average—sometimes one to two years later. Because symptoms like irregular periods, weight gain, and changes in skin or mood can occur with both PCOS and perimenopause, it can be difficult to tell which condition is driving the changes you may be experiencing.

How PCOS Changes with Menopause

While menstrual irregularities resolve once menopause begins, PCOS does not disappear. In fact, the focus shifts toward long-term health risks. Women with PCOS continue to face a higher risk of insulin resistance, type 2 diabetes, high cholesterol, and cardiovascular disease. Some symptoms of androgen excess, such as acne or hair growth, may improve, but for many women, they persist even after menopause.

Managing PCOS Through Menopause

Here are practical steps for managing PCOS and menopause together, especially to reduce risks and improve quality of life:

  1. Lifestyle
    • Maintain a healthy weight through balanced nutrition (with whole foods, lean protein, plenty of fiber) and regular physical activity.
    • Focus on good sleep hygiene and stress management—both affect hormones.
    • Avoid smoking; alcohol in moderation.
  2. Hormonal & Medical Treatments
    • Hormone therapy (if appropriate) to address menopausal symptoms.
    • Medications to manage insulin resistance (e.g. metformin) or regulate androgen levels.
    • Regular monitoring of lipids, blood sugar, and blood pressure.
  3. Regular Check-ups
    • See your endocrinologist or health provider to review labs and symptoms at least annually.
    • Screen for diabetes, heart disease, and other metabolic complications.
  4. Be Proactive
    • Work with your care team (endocrinologist, gynecologist, primary care) to tailor a plan based on how PCOS has affected you through your life.

Contact Texas Diabetes

If you have PCOS and are approaching perimenopause or already navigating menopause, Texas Diabetes is here to help. Our endocrinologists specialize in managing hormone changes, metabolic health, and long-term risks to ensure you receive the comprehensive care you deserve. 

If you’d like to schedule an appointment with one of our endocrinologists at Texas Diabetes & Endocrinology, please contact us at (512) 458-8400 or request an appointment online.  

Cortisol Cocktails Are Trending—But Do They Actually Work?

Are the trending cortisol cocktails a magic cure for adrenal disorders? Lately on social media platforms like TikTok, influencers are claiming health benefits such as stress relief and weight loss from special “cortisol cocktails” created to treat adrenal insufficiencies. Most experts, including our endocrinologists, say they are not truly effective. 

Adrenal disorders occur when the adrenal glands (which help regulate things like blood pressure, immunity, metabolism, and stress response) don’t produce the correct amount of hormones. 

Examples of adrenal disorders that our team of board-certified endocrinologists treat at TD&E include Cushing’s Syndrome, Hyperaldosteronism, Pheochromocytoma and Addison’s Disease or Adrenal Insufficiency. 

What is a cortisol cocktail? 

Cortisol cocktails claim to reduce the effects of cortisol/stress on the body (produced by the adrenal glands). Common ingredients in these concoctions include orange juice and coconut water as well as salt, cream of tarter, and ginger. 

Fans of these homemade potions claim that this unique combination of vitamins, potassium and sodium can heal the adrenal glands and prevent the excess production of cortisol. 

Not really so, says medical professionals and TD&E endocrinologist Dr. Jean Chen

“There is nothing dangerous or harmful in drinking this cocktail of ingredients,” says Dr. Chen.  “However, there is currently no scientific evidence to show that it has an actual effect on the adrenal glands. It’s best to seek guidance from an endocrinologist if you feel that you are suffering from adrenal insufficiency.”

Some common symptoms of adrenal insufficiency are:

  • Extreme fatigue 
  • Loss of appetite or sudden weight loss
  • Low blood pressure 
  •  Dizziness 
  • Darkened skin in areas with folds like the elbows, knees, and toes 

Effective Cortisol Management 

As these cortisol cocktails continue to trend on social media, or various versions of them are being sold online, doctors remind those who buy into the hype that real relief from adrenal fatigue or cortisol-induced stress largely comes from healthy habits like:

  • Eating a well-balanced diet
  • Exercising regularly 
  • Getting plenty of quality sleep (six to eight hours for most adults)
  • Seeking medical help when needed  

Depending on the condition, adrenal disorders are typically treated with medication, radiation therapy, and/or surgery. 

At TD&E, we are here to assist with your adrenal condition and explore the proven therapies to support your unique case and symptoms. 

Contact Us to Help Manage your Diabetes, Osteoporosis, Thyroid & Adrenal Conditions 

If you’d like to schedule an appointment with one of our specialists at Texas Diabetes & Endocrinology and discover how our diabetes services  and other endocrinology therapies can help you lead a full and active life, please contact us at (512) 458-8400 or request an appointment online.  

Clinical Trial Offers HypoPARA Patient New Lease on Life

Life with hypoparathyroidism has been a challenging journey for a Texas Diabetes patient,
who for the purposes of this blog will be referred to as “the patient”. Diagnosed at the age of
23 after their parathyroid glands were removed during thyroid cancer surgery, the 54-year old
Frisco resident has lived with the condition for over three decades.

Hypoparathyroidism is a rare condition where the parathyroid glands, located near the
thyroid in the neck, produce insufficient amounts of parathyroid hormone (PTH). PTH plays
a critical role in regulating calcium, phosphorus, and vitamin D levels in the blood and
bones.

“When I was diagnosed, there was no treatment for the disease, just medications to
manage the symptoms,” the patient recalls. Over the years, they relied on an exhausting
regimen of medications—up to 64 pills a day, taken every three hours—to keep their
calcium levels stable and avoid severe symptoms. Despite their best efforts, they faced
over 200 hospitalizations due to low calcium levels.

In 2019, the patient learned about a clinical trial for TransCon PTH, a new hormone
replacement therapy designed to restore physiologic levels of PTH. After speaking with
their endocrinologist, they applied to participate in the trial the day it went live on
ClinicalTrials.gov.

Within a week, they were contacted by Texas Diabetes & Endocrinology Research team to
begin the screening process. “The first four weeks were spent getting my blood levels
optimized for the trial,” they explain. The staff at Texas Diabetes played a critical role in
guiding them through this phase. “They communicated frequently and really walked me
through the process. It felt like I was the only patient they were working with.”

After successfully completing the optimization phase, the patient began the daily
injections, not knowing at the time if they were receiving the actual drug or a placebo.
Although the treatment regimen wasn’t easy at first, the team at Texas Diabetes was there
to support them.

Seeing Results

Soon, the patient experienced results beyond what they could have imagined – confirming
in their mind that they were receiving the actual drug. For the first time in decades, their
calcium levels stabilized, allowing themto gradually reduce and ultimately stop taking
daily pills.

“In less than six months of starting the trial, I was able to come off all my medications,”
they said. “I hadn’t been in range in over 30 years, and suddenly, I was.”

As their body adjusted to the new treatment, the symptoms that had plagued them for
years—numbness, tingling,muscle cramps, heart palpitations, fatigue and brain fog—
began to disappear.

“I didn’t realize how much brain fog I was living with until it lifted. I couldn’t remember the
names of everyday objects, and I would struggle to getmy thoughts out. But now, I feel like I
can think clearly again.”

Advocating for Change

With their newfound energy, the patient began volunteering for the HypoPARAthyroidism
Association
, a nonprofit dedicated to raising awareness and support for those living with
the condition. Passionate about helping others, their volunteer work quickly turned into
accepting a position on the board and eventually a full-time role with the organization.

One of their proudest accomplishments is spearheading an Externally Led – Patient
Focused Drug Development meeting with the FDA for PTH.

“You can read about symptoms on a page, but that doesn’t tell you how it impacts
someone’s daily life,” they explain. “I wanted the FDA to understand how
hypoparathyroidism affects real people.”

The meeting brought together patients and experts to share their experiences with the FDA.

Looking Forward

The FDA approved TransCon PTH and it is expected to come to market in early 2025. The
patient is grateful to Texas Diabetes for applying to be an early access provider so they can
continue to take the medication while waiting for it to become available.

Reflecting on their decades long journey, the patient emphasizes the importance of clinical
trials in advancing treatment options for rare conditions. “There’s a misnomer that you only
do a clinical trial when it’s your last hope, but that’s not the case” they say. “The drug has
given me a chance at life again, and I can’t thank Texas Diabetes enough for giving me the
opportunity to feel like a new human being.”

The patient hopes their story will inspire others to consider participating in clinical trials
and raise awareness of the transformative power they hold. “If I had to do it all over again, I
would, in a heartbeat. It has been life changing.”

You can learn more about our research department and currently enrolling clinical trials here. Please feel free to contact us at (512) 334-3505, option 4, to speak to a recruiter about our enrolling studies.

Don’t forget to follow us on Facebook and Instagram and check back with us eachmonth as we provide you helpful wellness and health information.

menopause and diabetes
What should you know about menopause and diabetes?

There’s no doubt that cases of diabetes are on the rise. In fact, experts predict that by the year 2050, one in every three adults in the United States could suffer from this chronic disease that disrupts hormones, affects how the body reacts to food and sugars (glucose), and can lead to obesity, heart disease and stroke if not managed properly.  

At Texas Diabetes & Endocrinology (TD&E), our board-certified endocrinology experts treat diabetes, along with other endocrinology disorders like osteoporosis, every day. 

One group in particular that is experiencing an uptick in diabetes diagnoses is menopausal women.  During menopause, estrogen levels decrease (because of diminishing ovarian reserves) which can cause weight gain leading to potential insulin resistance and difficulty metabolizing glucose. 

New research now shows that Type 2 Diabetes (T2D) is one of the most common health risks associated with postmenopausal women (up to age 55 years). 

This particular study evaluated 2,295 postmenopausal women and surveyed them and their propensity towards diabetes via blood tests, physical exams and measurements, and in-person interviews. 

Here’s what was found:

  • Lower levels of the hormones estrogen and progesterone are key factors in contributing to more cases of T2D in women over the age of 40
  • The prevalence of T2D increased in women with a greater BMI (Body Mass Index) and also elevated cholesterol levels 
  • Mood swings and hot flashes associated with menopause can cause poor sleep which is also a contributing factor to obesity, and therefore diabetes 

One of the most important things women can do to prevent diabetes brought on by menopause is to get screened.

“In support of recommendations by the American Diabetes Association, we suggest getting tested for diabetes every three years after the age of 45 if you are overweight or have a family history of the disease,”  says TD&E board-certified endocrinologist and diabetes expert Dr.  Jean Chen.

“Additionally, adopting a healthy lifestyle including eating a well-balanced, low fat and low cholesterol diet, and exercising regularly incorporating weight-bearing workouts can go a long way in helping to prevent diabetes as women approach menopause and this transitional phase in life.”

Diabetes Treatment for Women in Menopause 

Hormone Therapy (HT), or hormone replacement therapy and estrogen supplements, is the standard treatment for women experiencing severe menopausal symptoms. HT can help balance and regulate hormones which are depleted and improve symptoms like hot flashes, help with insulin function, and decrease the potential for developing diabetes. 

HT has also been shown to reduce the risk of osteoporosis (weakened bones), another common condition as women reach menopause. 

At TD&E, we offer individualized treatment plans to help effectively manage your diabetes through tools like weight management and insulin pumps.  We also provide extensive treatment options for osteoporosis and fracture prevention.  

Contact Us to Help Manage your Diabetes, Osteoporosis and Thyroid Conditions 

If you’d like to schedule an appointment with one of our specialists at Texas Diabetes & Endocrinology and discover how our diabetes services  and other endocrinology therapies can help you lead a full and active life, please contact us at (512) 458-8400 or request an appointment online.  

Don’t forget to follow us on Facebook and Instagram and check back with us each month as we provide you helpful wellness and health information.

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